Formulation and Evaluation of Zidovudine Matrix Tablets Using Dikamali

The aim of the present study is to evaluate the gum Dikamali as a sustained release polymer employing zidovudine as a model drug. Natural gums are economic, easily available and found useful as Pharmaceutical excipients. To the best of our knowledge, no significant work has been reported on dikamali. Zidovudine was received as a gift sample from Hetero Drugs Private limited (Jeedimetla, Hyderabad), Dikamali was received as a gift sample from Girijen Co-operative Corporation (Vishakapatnam). All the other chemicals used for the study are of Commercial grade. Zidovudine Matrix Tablets were prepared by Direct compression technique using dikamali. The prepared tablets were evaluated for Tapped density, Bulk density, Compressibility index, Hausner ratio, Angle of repose, Hardness, Friability, Weight variation, Thickness, Content uniformity. All the parameters were found to be within the limits. Dissolution studies performed for 10 different formulations containing Dikamali as a sustained release polymer in different concentrations like 10%, 15%, 20%, 25%, 30% with and without disintegrant. These Studies revealed that Dikamali at 30% concentration with disintegrant shows better sustaining property. The optimized formulation also subjected to different Kinetic models and it was shown that the formulation follows Higuchi model and from that it was concluded that the rate controlling mechanism is Diffusion. From the Korsmeyer Peppas equation it was found that drug release follows super case II transport. Future scope of this project is to use Dikamali as a binder for preparation of Zidovudine sustain release tablets